Dr. Tod Mikuriya, one of the world’s foremost authorities on the uses of medical Cannabis. He has few peers in his clinical knowledge of Cannabis’ therapeutic uses, efficacy, history, culture, policies, routes of administration and potential for abuse.
It has been observed by my office staff and confirmed anecdotally by colleagues that people seeking physician approval to medicate with Cannabis usually register body temperatures markedly below 98.6. Hypothermia in the mouse is one of the “classic tetrad” of symptoms indicating activation of the cannabinoid system. The genesis of hypothermia requires further study.
The Indian Hemp Drugs Commission observed that one of the reputed benefits was to help laborers tolerate the heat. Cannabis was described as used to cool the passions in contrast with alcohol, which heated them. A slower metabolic rate, over time, might have implications for longevity.
Clinically, Cannabis appears to actually lower temperature and a couple of patients have described a sense of cold with transient shivering. The question could be answered readily by comparing temperatures of persons who have THC metabolites in their urine and people who don’t. If there turns out to be a significantly lower temperature in the Cannabis-using population, one might posit a slower metabolic rate which, over time, might have implications for longevity.
Temperature has a significant effect on metabolic rate. We have to understand the mechanism of hypothermogenesis. If there is a hypothermia, what influence is there on the HPA (Hypothalamus Pituitary Adrenal networks)and all of the interactions affecting levels of circulating cortisol and epinephrine, etc.?
With management of diabetes, Cannabis decreases blood sugar by diminishing gluconeogenesis, which plays out in decreasedinsulin requirement and improved stability.
This hypothermogenic effect appears to be dose-related and could contribute to a neuroprotective effect after trauma. The optimum delivery method will require study. Hopefully, we will see a vaporizer on ambulances for treatment of head injury and seizures, and at the bedside of pre- and post-neurosurgery patients.
In addition to external cooling, Cannabis quiets the irritable CNS. A combination of inhaled and oral Cannabis would be appropriate for acute CNS trauma from internal or external etiology. I predict this will become accepted and mainstream in the future.
Raphael Mechoulam’s lab published a paper in 2003 showing that hypothermia appears to be an important factor as to why the synthetic THC analog HU-210 was protective in an animal model of stroke. [Leker,R.R., Gai, N., Mechoulam, R. and Ovadia, H. (2003)Drug-induced hypothermia reduces ischemic damage:effects of the cannabinoid HU-210. Stroke 34, 2000-2006]
… If a patient presents to an ER with a stroke,the first thing they will do is put the patient’s head in a cooler and pump them full of antioxidants (vitamin E).
MIKURIYA’S CONDITIONS TREATED WITH Cannabis
Physical, Mental, and Moral Effects of Marijuana:
The Indian Hemp Drugs Commission Report
Tod H. Mikuriya, M.D. San Francisco, California
The Indian Hemp Drugs Commission Report (1894), comprising some seven volumes and 3,281 pages, is by far the most complete and systematic study of marijuana undertaken to date.
Because of the rarity and, perhaps, the formidable size of this document, the wealth of information contained in it has not found its way into contemporary writings on this subject. This is indeed unfortunate, as many of the issues concerning marijuana being argued in the United States today were dealt with in the Indian Hemp Drugs Commission Report.
It is both surprising and gratifying to note the timeless and lucid quality of the writings of these British colonial bureaucrats. It would be fortunate if studies undertaken by contemporary commissions, task force committees, and study groups could measure up to the standards of thoroughness and general objectivity embodied in this report. In the current context of violently polarized attitudes toward marijuana, the prospect of a study of similar stature is bleak.
The scope of this paper is necessarily limited to the issues of physical, mental, and moral effects of hemp drugs as discussed in the report, although the topics of cultivation, processing, and administrative control schemes make up significant portions of the work itself.
The Indian Hemp Drugs Commission Report.
Major Studies of Drugs and Drug Policy.